Metoclopramide and the gastro-oesophageal sphincter
نویسندگان
چکیده
منابع مشابه
Effect of atropine on gastro-oesophageal reflux and transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux disease.
BACKGROUND Atropine reduces the rate of reflux episodes in normal subjects by inhibition of transient lower oesophageal sphincter (LOS) relaxations. The aim of this study was to investigate the effect of atropine on the rate and mechanisms of reflux in patients with reflux disease. METHODS Oesophageal motility and pH were recorded for one hour after a meal in 15 patients with reflux disease. ...
متن کاملEffect of pneumoperitoneum and Trendelenburg position on gastro-oesophageal reflux and lower oesophageal sphincter pressure.
We have measured the effect of pneumoperitoneum and the Trendelenburg position on lower oesophageal sphincter (LOSP) and barrier pressures (BrP) in 11 anaesthetized pigs while measuring the incidence of gastro-oesophageal reflux with a pH electrode. Propofol in combination with sufentanil had no effect on LOSP or BrP. Adoption of the Trendelenburg position with a pneumoperitoneum of 15 mm Hg re...
متن کاملCholinergic blockade inhibits gastro-oesophageal reflux and transient lower oesophageal sphincter relaxation through a central mechanism.
BACKGROUND Atropine, an anticholinergic agent with central and peripheral actions, reduces gastro-oesophageal reflux (GOR) in normal subjects and patients with gastro-oesophageal reflux disease (GORD) by inhibiting the frequency of transient lower oesophageal sphincter relaxation (TLOSR). AIMS To compare the effect of methscopolamine bromide (MSB), a peripherally acting anticholinergic agent,...
متن کاملEffect of intraduodenal fat on lower oesophageal sphincter function and gastro-oesophageal reflux.
BACKGROUND AND AIMS Fatty foods are commonly reported to aggravate gastro-oesophageal reflux symptoms. In this study the hypothesis that fat provokes reflux by stimulating transient lower oesophageal sphincter relaxations via small intestinal receptors was investigated. METHODS In 12 healthy volunteers and 11 patients with reflux oesophagitis, oesophageal motility and pH were measured over 30...
متن کاملSingle and combined effects of atropine and metoclopramide on the lower oesophageal sphincter pressure.
The effects of atropine and metoclopramide on the lower oesophageal sphincter pressure (LOSP) were studied in 12 healthy volunteers using oesophageal pressure transducers. Atropine decreased LOSP significantly at 5 min after i.v. injection (P less than 0.005) and this change was sustained for 60 min. Metoclopramide increased LOSP significantly at 3 min after administration i.v. (P less than 0.0...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1979
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1979.tb04887.x